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REMfresh FAQ - Featured FAQs

Our team of experts and doctors has answers.

When patients take REMfresh®, they may feel ready for sleep within 30 minutes to 90 minutes. If they wake up in the middle of the night while taking REMfresh®, they may find it easier to fall back asleep than with other melatonin products because of the unique release and absorption technology in REMfresh®. It is recommended that patients take REMfresh® when they are aiming for a fuller night’s sleep. The active ingredient in REMfresh®, melatonin, is neutralized by your patients’ morning production of cortisol. REMfresh®  is designed so patients wake up refreshed.

REMfresh®  has no added gluten, nuts, shellfish, or dairy products. REMfresh®  does contain dextrose monohydrate which is derived from wheat. Dextrose monohydrate is gluten free and is often used in gluten-free foods as a sweetener.

Start with 1 caplet of REMfresh®  30 to 90 minutes before desired bedtime. You should instruct your patients to titrate up until they achieve their desired results. Labeling suggests not to exceed 10 mg per night. REMfresh®  can be taken with or without food. REMfresh®  works best as part of a patient’s individualized Sleep Hygiene Cycle™.

Everyone reacts differently to melatonin. A study done with a 2 mg prolonged release melatonin product in Europe shows it should be taken up to 3 weeks to allow a fuller effect.17

No conclusive evidence is available. In the REMAKTTM trial, the treatment emergent adverse events (TEAE’s) in the conventional melatonin arm numbered 5 while the REMfresh®  arm had none. All 5 TEAE’s were CNS and GI in nature. The Cmax in the conventional melatonin arm was more than 23x the targeted maintenance threshold of 1000 pg/ml while the Cmax of REMfresh®  was less than 5x.

Take one to two caplets 30 – 90 minutes minutes before bedtime. Follow specific dosing instructions found on the back of the box.

When you take REMfresh®, you may start to feel ready for sleep within 30 – 90 minutes. If you do happen to wake up in the middle of the night while taking REMfresh, you may find that it is easier to fall back asleep than with other melatonin products. This is due to the unique continuous release and absorption technology in REMfresh®that provides up to 7 hours of sleep support.

REMfresh is a dietary supplement. REMfresh is regulated under the federal Dietary Supplement Health and Education Act, which does not require pre-approval. Melatonin has been in common and safe use for over two decades. REMfresh must submit all label claims to the FDA to keep on file but not for approval. The U.S. Food and Drug Administration (FDA) at all times has authority to investigate and monitor such products for safety and compliance.

When determining how much melatonin you should take for your individual sleep needs, you should start with a lower dose and then titrate up to achieve optimum results. Just be sure you don’t exceed more than 10 mg in one night. For best results, REMfresh should be taken 30 to 90 minutes before bed. In addition, REMfresh melatonin should be taken in conjunction with an overall healthy sleep hygiene program. The REMfresh Sleep Hygiene Cycle™ outlines some easy-to-follow tips so you can sleep better and, in turn, live better.

As with almost all supplements, no specific chronic use data is available. Please consult with your physician.

It is advised that you do not to split, crush or chew your REMfresh Advanced Ion-Powered Melatonin™ supplement. Because REMfresh was formulated with 7-hour continuous release and absorption technology, it should be taken as directed for a healthy night of sleep.

Melatonin is the body’s own sleep ingredient, and it has been commonly usedas a solution to combat occasional sleeplessness for decades. REMfresh is the #1 Sleep- Doctor Recommended melatonin brandand has 24 months of comprehensive safety data.It is  uncommon to experience side effects, however, as with any new supplement, you should always consult your physician.

When you take REMfresh®, you may start to feel ready for sleep within 30 – 90 minutes. If you do happen to wake up in the middle of the night while taking REMfresh, you may find that it is easier to fall back asleep than with other melatonin products. This is due to the unique continuous release and absorption technology in REMfresh®.

REMfresh® 2 mg and 5 mg are labeled for use by adults over age 18. REMfresh® recently introduced low-dose REMfresh® LITE for people with melatonin sensitivities, or those who require less melatonin or have a lower body weight. Low-dose melatonin is frequently recommended by doctors for patients 6 years and older. Consult a physician if using any supplement for the first time.

REMfresh is not intended for use by pregnant or nursing women.

Intended for occasional sleeplessness. Consult a physician before use: if you are under the age of 18; if you are experiencing long-term sleep difficulties; if pregnant, attempting to become pregnant, or nursing; if you have a medical condition, are taking medications, or have chronic diseases; if you are taking medication, or have chronic diseases; if you are taking sedatives, tranquilizers or any other sleep aid. If there are serious medical issues, REMfresh is not recommended. Do not drive or operate machinery when taking melatonin. Do not use when consuming alcohol. Keep out of reach of children. Store at room temperature. Do not use if blister is torn or ripped or if there is any other evidence of tampering. Consult a physician if using any supplement for the first time. The company will strive to keep information current and consistent but may not be able to do so at any specific time. Generally, the most current information can be found on www.REMfresh.com.

REMfresh has no added gluten, nuts, fish or dairy products. REMfresh® does contain dextrose monohydrate which is derived from wheat. Dextrose monohydrate is gluten free and is often used in gluten-free foods as a sweetener. If you have a wheat sensitivity, consult with your physician.

Learn more about REMfresh, please refer to our latest package insert. The company will strive to keep information current and consistent but may not be able to do so at any specific time. Generally, the most current information can be found on www.REMfresh.com.

In clinical trials, melatonin supplements have not been shown to be habit-forming.

(European Medicines Agency. Assessment Report for Circadin;2007. www.ema.europa.eu/docs/en_GB/document_library/…/WC500026808.pdf. Accessed July 11, 2019)

REMfresh is different from non-melatonin sleep products because it delivers the body’s own natural sleep ingredient, melatonin. Melatonin has not been shown to cause memory problems, morning dysfunction, drowsiness or unusual night occurrences such as sleepwalking. REMfresh® is non-habit forming and does not contain narcotics, hypnotics, barbiturates, sedatives, antihistamines, alcohol or other harsh additive chemicals.