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REMfresh FAQ - Melatonin

Our team of experts and doctors has answers.

Melatonin is the body’s own sleep hormone, produced by the pineal gland in the brain. Usually, melatonin release starts in the evening when the sun goes down, and then continues to be released throughout the night. If one were to look at a typical release pattern of melatonin throughout the night, on a graph, its shape would resemble a mesa, a flat-topped hill with steep sides.10 This pattern can be referred to as the Mesa Wave®.

As people age, their bodies may no longer produce enough melatonin for an adequate

Mesa Wave required for quality sleep.3,11

 

 

 

Melatonin is the body’s own sleep hormone. It plays an important role in sleep regulation.

Studies have shown that melatonin may help some people fall asleep. A European study of a prolonged-release melatonin demonstrated improvement in sleep onset, quality of sleep and morning alertness.(Wade AG, Ford I, Crawford G, et al. Efficacy of prolonged release melatonin in insomnia patients aged 55-80 years: quality of sleep and next-day alertness outcomes. Curr Med Res Opin. 2007;23(10):2597-2605.)

The half-life of conventional melatonin is less than 60 minutes, so sleep maintenance becomes a challenge. The patented Advanced Ion-Powered Pump™ technology delivery system in REMfresh® increases its half-life to provide up to 7 hours of sleep support.

Studies show that the amount of melatonin produced by the body decreases with age. Supplementing the body’s supply of melatonin can help some people experiencing occasional sleeplessness sleep better.

(Sack RL, Lewy AJ, Erb DL, et al. Human melatonin production decreases with age. J Pineal Res. 1986:3(4):379-388. PubMed CrossRef)(Wade AG, Ford I, Crawford G, et al. Efficacy of prolonged release melatonin in insomnia patients aged 55-80 years: quality of sleep and next-day alertness outcomes. Curr Med Res Opin. 2007;23(10):2597-2605.)

The body produces its peak adult melatonin levels in the teenage years. Then, like most hormones, melatonin levels begin to decline in production around age 30. There is a significant decrease in melatonin levels after the age of 40, which accelerates as you approach age 60.

(Sack RL, Lewy AJ, Erb DL, et al. Human melatonin production decreases with age. J Pineal Res. 1986:3(4):379-388. PubMed CrossRef)

Melatonin, the body’s own sleep ingredient, has a well-established profile of use. As with every new product you may take, you should consult with your physician.

(Melatonin. Monograph. Altern Med Rev. 2005:10(4):326-336. PubMed)

No serious side effects have been reported in association with taking melatonin. Non-serious side effects are also uncommon. Always consult with your physician before starting any new supplement or medication. Individual results may vary.

(Melatonin. Monograph. Altern Med Rev. 2005:10(4):326-336. PubMed)

As with almost all supplements, no comprehensive drug-interaction studies have been done with melatonin. Please consult with your physician.

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