The Benefits of Melatonin

As with every hormone, research shows melatonin levels typically decline with age. Melatonin levels begin to decline around age 30. Then, there is a significant decrease in melatonin levels after age 40, which accelerates as patients approach age 60.

Growing scientific data shows that melatonin supplementation can promote both improved sleep onset and maintenance in this patient population. However, until recently, the delivery of exogenous melatonin in the body has not been fully optimized for this purpose.

Melatonin Formulations

Conventional immediate-release (IR) melatonin formulations on the market can improve sleep onset but fail to address sleep quality and maintenance due to melatonin’s short half-life. Also, timed-release melatonin formulations do not faithfully replicate the body’s own melatonin release profile.

REMfresh®’s patented Ion-Powered Pump™ (IPP) technology is scientifically designed to address these limitations by mimicking the body’s own melatonin release profile. It allows melatonin to be continuously released and absorbed throughout the intestinal tract for up to 7 hours.

Clinical Data

Melatonin has been studied clinically for decades. Its efficacy and safety have been established by multiple studies worldwide. Below you will find links to the abstracts of key melatonin articles (for reference and medical education purposes only).

General Overview of Melatonin

Melatonin in Humans

The New England Journal of Medicine, 1997.

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Sleep-Inducing Effects of Melatonin

Sleep-Inducing Effects of Low Doses of Melatonin Ingested in the Evenings

(Harvard Medical School and MIT) Clinical Pharmacology & Therapeutics, 1995.

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Effects of Exogenous Melatonin on Sleep: A Meta-Analysis

(MIT, Boston University School of Medicine, University of Glasgow, UK, and Hadassah Medical Center, Israel) Sleep Medicine Reviews, 2005.

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Meta-Analysis: Melatonin for the Treatment of Primary Sleep Disorders

(Yale University, Children’s Hospital of Michigan, and University of São Paulo Medical School) PLOS One, 2013.

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Prolonged-Release Melatonin

Prolonged-Release Melatonin Improves Sleep Quality and Morning Alertness in Insomnia Patients Aged 55 Years and Older and Has No Withdrawal Effects

(The Clinique Lyon-Lumière, France; Neurim Pharmaceuticals, Israel; Tel Aviv University, Israel) Journal of Sleep Research, 2007.

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Prolonged-Release Melatonin for Insomnia – An Open-Label Long-Term Study of Efficacy, Safety, and Withdrawal

(The Clinique Lyon- Lumière, France; Shoham Geriatric Medical Center, Israel; Neurim Pharmaceuticals, Israel; Tel Aviv University, Israel) Therapeutics and Clinical Risk Management, 2011.

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Safety