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No conclusive evidence is available. In the REMAKT trial, the treatment emergent adverse events (TEAE’s) in the conventional melatonin arm numbered five while the REMfresh arm had none. All five TEAE’s were CNS or GI in nature. The Cmax in the conventional melatonin arm was more than 23 times the targeted maintenance threshold of 1000 pg/ml while the Cmax of REMfresh was less than five times.
We suggest patients start with one 2 mg or 5 mg caplet of REMfresh 30 to 90 minutes before their desired bedtime. You should instruct your patients to titrate up until they have achieved their desired results. Labeling suggests not to exceed 10 mg per night. REMfresh can be taken with or without food. REMfresh works best as part of a patient’s individualized Sleep Hygiene Cycle™. Everyone reacts differently to melatonin. A study done with a 2 mg prolonged release melatonin product in Europe shows it may take up to 3 weeks to allow a fuller effect of melatonin.
When patients take REMfresh, they may feel ready for sleep within 30 minutes to an hour.† If they wake up in the middle of the night while taking REMfresh, they may find it easier to fall back to sleep than with other melatonin products because of the unique release and absorption technology in REMfresh†. It is recommended that the patient take REMfresh when they are aiming for a fuller night’s sleep. The active ingredient in REMfresh, melatonin, is neutralized by your patient’s morning production of cortisol. REMfresh is designed so patients wake up refreshed.†
REMfresh has no added gluten, nuts, shellfish, or dairy products.
No. REMfresh is available without a prescription at select drug stores and on REMfresh.com and Amazon.com.
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This information is for educational purposes only and is not meant to be a substitute for the advice of a physician or other healthcare professional. It has not been reviewed by the FDA. You should not use this information for diagnosing a health problem or disease. Individual results may vary. The company will strive to keep information current and consistent, but may not be able to do so at any specific time.